High-volume forced diuresis with matched hydration using the RenalGuard System to prevent contrast-induced nephropathy: A meta-analysis of randomized trials.

ABSTRACT:

Background

Contrast-induced nephropathy (CIN) is a well-recognized complication of coronary angiography that is associated with poor outcomes. Several small randomized controlled trials (RCTs) have recently shown that in patients with chronic kidney disease (CKD), furosemide-induced forced diuresis with matched hydration using the RenalGuard system can prevent its occurrence. However, individual studies have been underpowered and thus cannot show significant differences in major clinical endpoints.

Hypothesis

Forced diuresis with matched hydration using the RenalGuard system improves clinical outcomes in patients undergoing coronary angiography.

Methods

Scientific databases and websites were searched for relevant RCTs. The pooled risk ratios were calculated using rand

SUBMITTER: Shah R 

PROVIDER: S-EPMC6490568 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature