Statin Use and Aneurysm Risk in Patients With Bicuspid Aortic Valve Disease.

ABSTRACT:

Background

No medical therapy has been proven to prevent the progression of aortic dilatation in bicuspid aortic valve (BAV) disease, and prophylactic aortic surgery remains the mainstay of treatment.

Hypothesis

Among patients with BAV disease who are referred for surgery, preoperative statin use is associated with decreased odds of ascending aortic dilatation.

Methods

We reviewed all BAV patients who underwent aortic valve and/or aortic surgery at our center between April 2004 and December 2013. Aortic diameter (AD), defined as the maximum ascending aortic dimension, was determined by magnetic resonance imaging, computed tomography, or echocardiography. Patients were divided into 2 groups: maximal AD <4.5 cm or ≥4.5 cm. The association between preoperative statin use

SUBMITTER: Taylor AP 

PROVIDER: S-EPMC6490730 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature