Nonsteroidal Anti-inflammatory Drugs and Risk of Incident Heart Failure: A Systematic Review and Meta-analysis of Observational Studies.

ABSTRACT:

Background

The association between the development of heart failure (HF) and use of nonsteroidal anti-inflammatory drugs (NSAIDs) is not well established.

Hypothesis

Use of NSAIDs may increase the risk of incident HF.

Methods

We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio comparing risk of incident HF in NSAID users vs nonusers. Pooled risk ratios (RR) and 95% confidence intervals (CI) for all NSAIDs and both subclasses (conventional NSAIDs and highly selective cyclooxygenase-2 inhibitors [COXIBs]) were calculated using a random-effect, generic inverse variance method.

Results

Seven studies with 7,543,805 participants were identified and included

SUBMITTER: Ungprasert P 

PROVIDER: S-EPMC6490752 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature