Circulating Microparticles Decrease After Cardiac Stress in Patients With Significant Coronary Artery Stenosis.

ABSTRACT:

Background

Cardiac stress leads to a dynamic increase of circulating microparticles (MPs) in healthy individuals that is diminished in individuals with vascular disease. The impact of coronary ischemia on circulating MP level is unknown. This study investigates the kinetics of circulating MPs during cardiac stress in patients with coronary artery stenosis.

Hypothesis

Patients with significant coronary stenosis show altered circulating MP levels after cardiac stress.

Methods

Eighty patients with stable coronary artery disease underwent dobutamine stress echocardiography (DSE) on the day before coronary angiography. Before, immediately after, at 4 hours, and at 24 hours after DSE, blood was drawn to determine CD144⁺ endothelial microparticles (EMPs), CD14

SUBMITTER: Sinning JM 

PROVIDER: S-EPMC6490784 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature