Similar Impact of Clopidogrel or Ticagrelor on Carotid Atherosclerotic Plaque Inflammation.

ABSTRACT:

Background

Platelets play an important role in inflammation. Inhibitors of the P2Y₁₂ receptor, which is involved in platelet activation, may have a direct effect on carotid atherosclerotic plaque inflammation.

Hypothesis

We compared the effects of clopidogrel and ticagrelor therapy for carotid atherosclerotic plaque inflammation using ¹⁸ F-fluorodeoxyglucose ( ¹⁸ FDG) positron emission tomography (PET) imaging.

Methods

Fifty patients with acute coronary syndrome and ≥1 ¹⁸ FDG uptake in the carotid artery (target-to-background ratio [TBR] ≥1.6) were randomized to either clopidogrel or ticagrelor groups. Of these, 46 completed PET examinations at baseline and at 6 months. The primary endpoint was the percent change in TBR of t

SUBMITTER: Oh M 

PROVIDER: S-EPMC6490841 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature