Longitudinal Relationship Between Frailty and Cognition in Patients 50 Years and Older with Breast Cancer.

ABSTRACT:

Objectives

To evaluate relationships between frailty and cognition longitudinally in adults 50 years and older with breast cancer receiving chemotherapy.

Design

Secondary analysis of a prospective longitudinal observational study.

Setting

University of Rochester NCI Community Oncology Research Program community oncology clinics.

Participants

Patients with breast cancer age 50 and older receiving adjuvant/neoadjuvant chemotherapy (n = 376) and age-matched controls without cancer (n = 234).

Measurements

Frailty was assessed using a modified frailty score from self-reported assessments (weakness, exhaustion, physical activity, and gait speed). Cognition was assessed by patient report (Functional Assessment of Cancer Therapy-Cognition [FACT-Cog]) and objecti

SUBMITTER: Magnuson A 

PROVIDER: S-EPMC6490967 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature