Oscillatory hyperactivity and hyperconnectivity in young <i>APOE</i>-ɛ4 carriers and hypoconnectivity in Alzheimer's disease.

ABSTRACT: We studied resting-state oscillatory connectivity using magnetoencephalography in healthy young humans (N = 183) genotyped for APOE-ɛ4, the greatest genetic risk for Alzheimer's disease (AD). Connectivity across frequencies, but most prevalent in alpha/beta, was increased in APOE-ɛ4 in a set of mostly right-hemisphere connections, including lateral parietal and precuneus regions of the Default Mode Network. Similar regions also demonstrated hyperactivity, but only in gamma (40-160 Hz). In a separate study of AD patients, hypoconnectivity was seen in an extended bilateral network that partially overlapped with the hyperconnected regions seen in young APOE-ɛ4 carriers. Using machine-learning, AD patients could be distinguished from elderly controls with reasonable sensitivity and specificity

SUBMITTER: Koelewijn L 

PROVIDER: S-EPMC6491037 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature