Pharmacological stress impairs working memory performance and attenuates dorsolateral prefrontal cortex glutamate modulation.

ABSTRACT: Working memory processes are associated with the dorsolateral prefrontal cortex (dlPFC). Prior research using proton functional magnetic resonance spectroscopy (¹H fMRS) observed significant dlPFC glutamate modulation during letter 2-back performance, indicative of working memory-driven increase in excitatory neural activity. Acute stress has been shown to impair working memory performance. Herein, we quantified dlPFC glutamate modulation during working memory under placebo (oral lactose) and acute stress conditions (oral yohimbine 54 mg + hydrocortisone 10 mg). Using a double-blind, randomized crossover design, participants (N = 19) completed a letter 2-back task during left dlPFC ¹H fMRS acquisition (Brodmann areas 45/46; 4.5 cm³). An automated fitting pr

SUBMITTER: Woodcock EA 

PROVIDER: S-EPMC6491044 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature