Three-dimensional ultrashort echo time imaging with tricomponent analysis for human cortical bone.

ABSTRACT:

Purpose

To investigate tricomponent analysis of human cortical bone using a multipeak fat signal model with 3D ultrashort TE Cones sequences on a clinical 3T scanner.

Methods

Tricomponent fitting of bound water, pore water, and fat content using a multipeak fat spectra model was proposed for 3D ultrashort TE imaging of cortical bone. Three-dimensional ultrashort TE Cones acquisitions combined with tricomponent analysis were used to investigate bound and pore water T2∗ and fractions, as well as fat T2∗ and fraction in cortical bone. Feasibility studies were performed on 9 human cortical bone specimens with regions of interest selected from the endosteum to the periosteum in 4 circumferential regions. Microcomputed tomography studies were performed to measure bone porosity and

SUBMITTER: Lu X 

PROVIDER: S-EPMC6491227 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature