Lower sarcoplasmic reticulum Ca²⁺ threshold for triggering afterdepolarizations in diabetic rat hearts.

ABSTRACT:

Background

Type 2 diabetes (T2D) increases arrhythmia risk through incompletely elucidated mechanisms. Ventricular arrhythmias could be initiated by delayed afterdepolarizations (DADs) resulting from elevated spontaneous sarcoplasmic reticulum (SR) Ca²⁺ release (SR Ca²⁺ leak).

Objective

The purpose of this study was to test the role of DADs and SR Ca²⁺ leak in triggering arrhythmias in T2D hearts.

Methods

We compared rats with late-onset T2D that display pancreatic and cardiac phenotypes similar to those in humans with T2D (HIP rats) and their nondiabetic littermates (wild type [WT]).

Results

HIP rats showed higher propensity for premature ventricular complexes and ventricular tachyarrhythmias, whereas HIP myocytes displayed mor

SUBMITTER: Popescu I 

PROVIDER: S-EPMC6491240 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature