Simultaneous editing of GABA and GSH with Hadamard-encoded MR spectroscopic imaging.

ABSTRACT:

Purpose

To evaluate the feasibility of simultaneous MR spectroscopic imaging (MRSI) of gamma-aminobutyric acid (GABA) and glutathione (GSH) in the human brain using Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy (HERMES).

Methods

Point RESolved Spectroscopy (PRESS)-localized MRSI was performed in GABA and GSH phantoms and in the human brain (n = 3) using HERMES editing and compared to conventional MEGA editing of each metabolite. Multiplet patterns, signal intensities, and metabolite crosstalk were compared between methods. GABA+ and GSH levels were compared between methods for bias and variability. Linear regression of HERMES-MRSI GABA+/H₂ O and GSH/H₂ O versus gray matter (GM) fraction were performed to assess differences between GM

SUBMITTER: Chan KL 

PROVIDER: S-EPMC6491241 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature