Correlation between systemic inflammatory response and quality of life in patients with chronic rhinosinusitis.

ABSTRACT:

Background

Local sinonasal inflammation resulting from altered T-cell immune signaling is a contributor to the pathogenesis of chronic rhinosinusitis (CRS). CRS patients experience negative impacts on quality of life (QOL) and suffer from comorbidities linked to systemic inflammation. However, systemic inflammatory profiling to evaluate the association between systemic inflammation and QOL in CRS has not been performed. Our objectives were to compare local and systemic inflammatory gene expression in patients with CRS to determine if systemic markers of inflammation associate with disease severity and disease-specific QOL.

Methods

A prospective observational study was conducted comparing 16 patients with CRS to 10 controls. Inflammatory gene expression in the anterior ethmoi

SUBMITTER: Orb Q 

PROVIDER: S-EPMC6491244 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature