Immunometabolism is a key factor for the persistent spontaneous elite control of HIV-1 infection.

ABSTRACT:

Background

Approximately 25% of elite controllers (ECs) lose their virological control by mechanisms that are only partially known. Recently, immunovirological and proteomic factors have been associated to the loss of spontaneous control. Our aim was to perform a metabolomic approach to identify the underlying mechanistic pathways and potential biomarkers associated with this loss of control.

Methods

Plasma samples from EC who spontaneously lost virological control (Transient Controllers, TC, n = 8), at two and one year before the loss of control, were compared with a control group of EC who persistently maintained virological control during the same follow-up period (Persistent Controllers, PC, n = 8). The determination of metabolites and plasma lipids was performed by GC-q

SUBMITTER: Tarancon-Diez L 

PROVIDER: S-EPMC6491381 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature