Boronic Acid Appended Naphthyl-Pyridinium Receptors as Chemosensors for Sugars.

ABSTRACT: There remains a need in clinics and research to have simple and sensitive detection systems that allow the detection and quantification of sugar markers of biomedical relevance such as sugars lactulose and mannitol for noninvasive gut permeability assessment. We have prepared a new class of boronic acid-appended naphthyl-pyridinium receptor compounds as chemosensors. These were studied for their ability to act as modular internal charge transfer (ICT) fluorescent probes or donor/acceptor pair ensembles where the receptor compound can act as a quencher for an anionic dye. As an ICT sensor, fluorescence intensity increased upon diol recognition, which stems from the neutralization of the pyridinium nitrogen that is perturbing the chromophoric properties. We found these ICT probes provide goo

SUBMITTER: Resendez A 

PROVIDER: S-EPMC6491427 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature