Antibiotic-Induced Disruption of Gut Microbiota Alters Local Metabolomes and Immune Responses.

ABSTRACT: Gut microbiome plays an essential role in modulating host immune responses. However, little is known about the interaction of microbiota, their metabolites and relevant inflammatory responses in the gut. By treating the mice with three different antibiotics (enrofloxacin, vancomycin, and polymixin B sulfate), we aimed to investigate the effects of different antibiotics exposure on gut microbiota, microbial metabolism, inflammation responses in the gut, and most importantly, pinpoint the underlying interactions between them. Although the administration of different antibiotics can lead to different effects on mouse models, the treatment did not affect the average body weight of the mice. A heavier caecum was observed in vancomycin treated mice. Treatment by these three antibiotics significa

SUBMITTER: Sun L 

PROVIDER: S-EPMC6491449 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature