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Production of IgG2 Antibodies to Pneumococcal Polysaccharides After Vaccination of Treated HIV Patients May Be Augmented by IL-7Rα Signaling in ICOS⁺ Circulating T Follicular-Helper Cells.

ABSTRACT: Greater understanding of factors influencing the maturation of antibody responses against pneumococcal polysaccharides (PcPs) may improve pneumococcal vaccination strategies. Although PcPs are type 2 T cell-independent antigens thought not to induce follicular immune responses, we have previously shown that IgG2 antibody responses against antigens in the 23-valent unconjugated PcP vaccine (PPV23) are associated with expansion of ICOS⁺ circulating T follicular helper (cT_FH) cells in HIV seronegative subjects but not HIV patients. As IL-7Rα signaling in CD4⁺ T cells may affect T_FH cell function and is adversely affected by HIV-1 infection, we have examined the relationship of IL-7Rα expression on ICOS⁺ cT_FH cells with PcP-spec

SUBMITTER: Abudulai LN

PROVIDER: S-EPMC6491457 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Dataset Information

Production of IgG2 Antibodies to Pneumococcal Polysaccharides After Vaccination of Treated HIV Patients May Be Augmented by IL-7Rα Signaling in ICOS⁺ Circulating T Follicular-Helper Cells.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Production of IgG2 Antibodies to Pneumococcal Polysaccharides After Vaccination of Treated HIV Patients May Be Augmented by IL-7Rα Signaling in ICOS+ Circulating T Follicular-Helper Cells.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Production of IgG2 Antibodies to Pneumococcal Polysaccharides After Vaccination of Treated HIV Patients May Be Augmented by IL-7Rα Signaling in ICOS⁺ Circulating T Follicular-Helper Cells.