Association of hemoglobin A1C with circulating metabolites in Dutch with European, African Surinamese and Ghanaian background.

ABSTRACT:

Background

The prevalence of type 2 diabetes mellitus (T2DM) varies significantly across ethnic groups. A better understanding of the mechanisms underlying the variation in different ethnic groups may help to elucidate the pathophysiology of T2DM. The present work aims to generate a hypothesis regarding "why do subjects with African background have excess burden of T2DM?".

Methods

In the current study, we performed metabolite profiling of plasma samples derived from 773 subjects of three ethnic groups (Dutch with European, Ghanaian and African Surinamese background). We performed Bayesian lognormal regression analyses to assess associations between HbA1c and circulating metabolites.

Results

Here we show that subjects with African Surinamese and Ghanaian background had

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6491479 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature