Effects of human antimicrobial cryptides identified in apolipoprotein B depend on specific features of bacterial strains.

ABSTRACT: Cationic Host Defense Peptides (HDPs) are endowed with a broad variety of activities, including direct antimicrobial properties and modulatory roles in the innate immune response. Even if it has been widely demonstrated that bacterial membrane represents the main target of peptide antimicrobial activity, the molecular mechanisms underlying membrane perturbation by HDPs have not been fully clarified yet. Recently, two cryptic HDPs have been identified in human apolipoprotein B and found to be endowed with a broad-spectrum antimicrobial activity, and with anti-biofilm, wound healing and immunomodulatory properties. Moreover, ApoB derived HDPs are able to synergistically act in combination with conventional antibiotics, while being not toxic for eukaryotic cells. Here, by using a multidiscipl

SUBMITTER: Gaglione R 

PROVIDER: S-EPMC6491590 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature