Oleoylethanolamide Modulates BDNF-ERK Signaling and Neurogenesis in the Hippocampi of Rats Exposed to Δ⁹-THC and Ethanol Binge Drinking During Adolescence.

ABSTRACT: Oleoylethanolamide is an endogenous NAE that modulates ethanol-seeking behavior and ethanol-induced neuroinflammation. In the present study we further analyze the role of OEA in hippocampal neurogenesis, BDNF-ERK signaling, and spatial memory that are affected by alcohol. Additionally, we addressed the effects of OEA on the association of alcohol and cannabis, a frequent combination in human alcohol addicts, and whose long-term effects are far from being understood. To this end, OEA (10 mg/kg/day, i.p.) was pharmacologically administered for 5 days/week in a preclinical model of adolescent rats with binge-like consumption (1 day/week) of ethanol (3 g/kg, i.g.) combined or not with acute administrations of Δ⁹-THC (5 mg/kg, i.p.) for 5 weeks. OEA restored ethanol/THC-related decre

SUBMITTER: Silva-Pena D 

PROVIDER: S-EPMC6491684 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature