3D Reconstruction of the Intracortical Volume Around a Hybrid Microelectrode Array.

ABSTRACT: Extensive research using penetrating electrodes implanted in the central and peripheral nervous systems has been performed for many decades with significant advances made in recent years. While penetrating devices provide proximity to individual neurons in vivo, they suffer from declining performance over the course of months and often fail within a year. 2D histology studies using serial tissue sections have been extremely insightful in identifying and quantifying factors such as astroglial scar formation and neuronal death around the implant sites that may be contributing to failures. However, 2D histology has limitations in providing a holistic picture of the problems occurring at the electrode-tissue interface and struggles to analyze tissue below the electrode tips where the el

SUBMITTER: Nambiar A 

PROVIDER: S-EPMC6491727 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature