Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model.

ABSTRACT: Colorectal cancer (CRC) is the third most common cancer worldwide. Its incidence is still increasing, and the mortality rate is high. New therapeutic and prognostic strategies are urgently needed. It became increasingly recognized that the gut microbiota composition differs significantly between healthy people and CRC patients. Thus, identifying the difference between gut microbiota of the healthy people and CRC patients is fundamental to understand these microbes' functional roles in the development of CRC. We studied the microbial community structure of a CRC metagenomic dataset of 156 patients and healthy controls, and analyzed the diversity, differentially abundant bacteria, and co-occurrence networks. We applied a modified zero-inflated lognormal (ZIL) model for estimating the relativ

SUBMITTER: Ai D 

PROVIDER: S-EPMC6491826 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature