Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia.

ABSTRACT: Cardiac defibrillation to terminate lethal ventricular arrhythmia (VA) is currently performed by applying high energy electrical shocks. In cardiac tissue, electrical shocks induce simultaneously de- and hyperpolarized areas and only depolarized areas are considered to be responsible for VA termination. Because electrical shocks do not allow proper control over spatial extent and level of membrane potential changes, the effects of hyperpolarization have not been explored in the intact heart. In contrast, optogenetic methods allow cell type-selective induction of de- and hyperpolarization with unprecedented temporal and spatial control. To investigate effects of cardiomyocyte hyperpolarization on VA termination, we generated a mouse line with cardiomyocyte-specific expression of the light-d

SUBMITTER: Funken M 

PROVIDER: S-EPMC6491897 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature