Fatty Acid Signaling Mechanisms in Neural Cells: Fatty Acid Receptors.

ABSTRACT: Fatty acids (FAs) are typically associated with structural and metabolic roles, as they can be stored as triglycerides, degraded by β-oxidation or used in phospholipids' synthesis, the main components of biological membranes. It has been shown that these lipids exhibit also regulatory functions in different cell types. FAs can serve as secondary messengers, as well as modulators of enzymatic activities and substrates for cytokines synthesis. More recently, it has been documented a direct activity of free FAs as ligands of membrane, cytosolic, and nuclear receptors, and cumulative evidence has emerged, demonstrating its participation in a wide range of physiological and pathological conditions. It has been long known that the central nervous system is enriched with poly-unsaturated FAs, suc

SUBMITTER: Falomir-Lockhart LJ 

PROVIDER: S-EPMC6491900 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature