Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lung.

ABSTRACT:

Background

Genomic investigation of atypical adenomatous hyperplasia (AAH), the only known precursor lesion to lung adenocarcinomas (LUAD), presents challenges due to the low mutant cell fractions. This necessitates sensitive methods for detection of chromosomal aberrations to better study the role of critical alterations in early lung cancer pathogenesis and the progression from AAH to LUAD.

Methods

We applied a sensitive haplotype-based statistical technique to detect chromosomal alterations leading to allelic imbalance (AI) from genotype array profiling of 48 matched normal lung parenchyma, AAH and tumor tissues from 16 stage-I LUAD patients. To gain insights into shared developmental trajectories among tissues, we performed phylogenetic analyses and integrated our result

SUBMITTER: Sivakumar S 

PROVIDER: S-EPMC6491940 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature