Development and validation of a TP53-associated immune prognostic model for hepatocellular carcinoma.

ABSTRACT:

Background

TP53 mutation is the most common mutation in hepatocellular carcinoma (HCC), and it affects the progression and prognosis of HCC. We investigated how TP53 mutation regulates the HCC immunophenotype and thus affects the prognosis of HCC.

Methods

We investigated TP53 mutation status and RNA expression in different populations and platforms and developed an immune prognostic model (IPM) based on immune-related genes that were differentially expressed between TP53^WT and TP53^MUT HCC samples. Then, the influence of the IPM on the immune microenvironment in HCC was comprehensively analysed.

Findings

TP53 mutation resulted in the downregulation of the immune response in HCC. Thirty-seven of the 312 immune response-related genes were differenti

SUBMITTER: Long J 

PROVIDER: S-EPMC6491941 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature