Dynamic expression of Drosophila segmental cell surface-encoding genes and their pair-rule regulators.

ABSTRACT: Drosophila segmentation is regulated by a complex network of transcription factors that include products of the pair-rule genes (PRGs). PRGs are expressed in early embryos in the primorida of alternate segmental units, establishing the repeated, segmental body plan of the fly. Despite detailed analysis of the regulatory logic among segmentation genes, the relationship between these genes and the morphological formation of segments is still poorly understood, since regulation of transcription factor expression is not sufficient to explain how segments actually form and are maintained. Cell surface proteins containing Leucine rich repeats (LRR) play a variety of roles in development, and those expressed in segmental patterns likely impact segment morphogenesis. Here we explore the relationsh

SUBMITTER: Graham PL 

PROVIDER: S-EPMC6492026 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature