Clinical spectrum of cutaneous melanoma morphology.

ABSTRACT:

Background

Melanoma can mimic other cutaneous lesions, but the full spectrum and prevalence of these morphologic variants remain largely unknown.

Objective

To classify nonacral cutaneous melanomas into distinct morphologic clusters and characterize clusters' clinicopathologic features.

Methods

All pathologic melanoma diagnoses (occurring during 2011-2016) were reviewed for routine prebiopsy digital photographs (n = 400). Six dermatologists independently assigned lesions into 1 of 14 diagnostic classes on the basis of morphology. Image consensus clusters were generated by K-means; clinicopathologic features were compared with analysis of variance and χ².

Results

Five morphologic clusters were identified: typical (n = 136), nevus-like (n = 81), amelano

SUBMITTER: Klebanov N 

PROVIDER: S-EPMC6492030 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature