Association of bone mineral density and fat fraction with magnetic susceptibility in inflamed trabecular bone.

ABSTRACT:

Purpose

To evaluate the relationship between bone mineral density (BMD) and magnetic susceptibility, and between proton density fat fraction and susceptibility, in inflamed trabecular bone.

Methods

Two different phantoms modeling the fat fraction (FF) and BMD values of healthy bone marrow and disease states were scanned using a multiecho gradient echo acquisition at 3T. After correction for fat-water chemical shift, susceptibility mapping was performed, and susceptibility measurements were compared with BMD and FF values using linear regression. Patients with spondyloarthritis were scanned using the same protocol, and susceptibility values were calculated in areas of inflamed bone (edema) and fat metaplasia, both before and after accounting for the contribution of fat to the

SUBMITTER: Bray TJP 

PROVIDER: S-EPMC6492090 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature