Exposure measurement error when assessing current glucocorticoid use using UK primary care electronic prescription data.

ABSTRACT:

Purpose

To quantify misclassification in glucocorticoid (GC) exposure defined using UK primary care prescription data.

Methods

A cross-sectional study including patients with rheumatoid arthritis prescribed oral GCs in the past 2 years. Glucocorticoid exposure based on electronic prescription records was compared with participant-reported GC use captured using a paper diary. Prescription data (containing information about prescriptions issued but no dispensing information) was provided by the Clinical Practice Research Datalink. The following variables were defined: current use and dose of oral GCs and if (and when) participants had received a GC injection. For oral GCs, self-reported use was taken to represent "true" exposure. A dataset representing a hypothetical populatio

SUBMITTER: Joseph RM 

PROVIDER: S-EPMC6492099 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature