Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells.

ABSTRACT: Under homeostatic conditions, dendritic cells (DCs) continuously patrol the intestinal lamina propria. Upon antigen encounter, DCs initiate C-C motif chemokine receptor 7 (CCR7) expression and migrate into lymph nodes to direct T cell activation and differentiation. The mechanistic underpinnings of DC migration from the tissues to lymph nodes have been largely elucidated, contributing greatly to our understanding of DC functionality and intestinal immunity. In contrast, the molecular mechanisms allowing DCs to efficiently migrate through the complex extracellular matrix of the intestinal lamina propria prior to antigen encounter are still incompletely understood. Here we show that small intestinal murine CD11b⁺ CD103⁺ DCs express Placenta-expressed transcript 1 (Plet1

SUBMITTER: Karrich JJ 

PROVIDER: S-EPMC6492104 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature