Coupling between cerebral blood flow and cerebral blood volume: Contributions of different vascular compartments.

ABSTRACT: A better understanding of the coupling between changes in cerebral blood flow (CBF) and cerebral blood volume (CBV) is vital for furthering our understanding of the BOLD response. The aim of this study was to measure CBF-CBV coupling in different vascular compartments during neural activation. Three haemodynamic parameters were measured during a visual stimulus. Look-Locker flow-sensitive alternating inversion recovery was used to measure changes in CBF and arterial CBV (CBV_a ) using sequence parameters optimized for each contrast. Changes in total CBV (CBV_tot ) were measured using a gadolinium-based contrast agent technique. Haemodynamic changes were extracted from a region of interest based on voxels that were activated in the CBF experiments. The CBF-CBV_tot

SUBMITTER: Wesolowski R 

PROVIDER: S-EPMC6492110 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature