Systematic review: outcomes and adverse events from randomised trials in Crohn's disease.

ABSTRACT:

Background

The suitability of disease activity indices has been challenged, with growing interest in objective measures of inflammation.

Aim

To undertake a systematic review of efficacy and safety outcomes in placebo-controlled randomised controlled trials (RCTs) of patients with Crohn's disease.

Methods

MEDLINE, EMBASE, CINAHL and Cochrane Library were searched until November 2015, for RCTs of adult Crohn's disease patients treated with medical or surgical therapies. Data on efficacy and safety outcomes, end-point definitions, and measurement instruments were extracted and stratified by publication date (pre-2009 and 2009 onwards).

Results

One hundred and eighty-one RCTs (110 induction and 71 maintenance) were identified, including 23 850 patients. About 92.3%

SUBMITTER: Catt H 

PROVIDER: S-EPMC6492112 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature