White matter alterations and tract lateralization in children with dyslexia and isolated spelling deficits.

ABSTRACT: The present study investigated whether children with a typical dyslexia profile and children with isolated spelling deficits show a distinct pattern of white matter alteration compared with typically developing peers. Relevant studies on the topic are scarce, rely on small samples, and often suffer from the limitations of conventional tensor-based methods. The present Constrained Spherical Deconvolution study includes 27 children with typical reading and spelling skills, 21 children with dyslexia and 21 children with isolated spelling deficits. Group differences along major white matter tracts were quantified utilizing the Automated Fiber Quantification software and a lateralization index was calculated in order to investigate the structural asymmetry of the tracts. The two deficit groups

SUBMITTER: Banfi C 

PROVIDER: S-EPMC6492145 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature