Mapping tissue water T₁ in the liver using the MOLLI T₁ method in the presence of fat, iron and B₀ inhomogeneity.

ABSTRACT: Modified Look-Locker inversion recovery (MOLLI) T₁ mapping sequences can be useful in cardiac and liver tissue characterization, but determining underlying water T₁ is confounded by iron, fat and frequency offsets. This article proposes an algorithm that provides an independent water MOLLI T₁ (referred to as on-resonance water T₁ ) that would have been measured if a subject had no fat and normal iron, and imaging had been done on resonance. Fifteen NiCl₂ -doped agar phantoms with different peanut oil concentrations and 30 adults with various liver diseases, nineteen (63.3%) with liver steatosis, were scanned at 3 T using the shortened MOLLI (shMOLLI) T₁ mapping, multiple-echo spoiled gradient-recalled echo and ¹ H

SUBMITTER: Mozes FE 

PROVIDER: S-EPMC6492199 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature