Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention.

ABSTRACT: Vascular tumors are neoplasms of endothelial cells, a significant number of which present in childhood. Recent studies have examined the mutational landscape of many subtypes of vascular tumors, identifying mutations primarily within the Ras-mitogen-activated protein kinase (MAPK) pathway and providing a unique opportunity to consider targeted therapeutics. This review will summarize the current understanding of childhood vascular tumor pathobiology.

SUBMITTER: Cheraghlou S 

PROVIDER: S-EPMC6492225 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature