Pharmacological Management of Delirium in the Intensive Care Unit: A Randomized Pragmatic Clinical Trial.

ABSTRACT:

Background/objective

Delirium in the intensive care units (ICUs) is prevalent, with both delirium duration and delirium severity associated with adverse outcomes. We designed a pragmatic trial to test the efficacy of a pharmacological management of delirium (PMD) bundle in improving delirium/coma-free days and reducing delirium severity among ICU patients.

Design

A randomized pragmatic clinical trial.

Setting

Medical, surgical, and progressive ICUs of three tertiary care hospitals.

Participants

A total of 351 critically ill patients.

Intervention

A multicomponent PMD bundle consisting of reducing the exposure to 20 definite anticholinergic medications and benzodiazepines and prescribing low-dose haloperidol.

Measurements

The primary outcomes were

SUBMITTER: Khan BA 

PROVIDER: S-EPMC6492267 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature