A modular transcriptome map of mature B cell lymphomas.

ABSTRACT:

Background

Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt's lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma.

Methods

We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on

SUBMITTER: Loeffler-Wirth H 

PROVIDER: S-EPMC6492344 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature