Acute and subacute effects of oropharyngeal sensory stimulation with TRPV1 agonists in older patients with oropharyngeal dysphagia: a biomechanical and neurophysiological randomized pilot study.

ABSTRACT:

Background

Older people with oropharyngeal dysphagia (OD) present a decline in pharyngeal sensory function. The aim of this proof-of-concept study was to assess the biomechanical and neurophysiological effects of acute and subacute oropharyngeal sensory stimulation with transient receptor potential vanilloid 1 (TRPV1) agonists (capsaicinoids) in older patients with OD.

Methods

We studied the effect of a single dose versus multiple doses (2 weeks) of oral capsaicin treatment (10^-5 M) or placebo in 28 older patients with OD (81.2 ± 4.6 years) using videofluoroscopy (penetration-aspiration scale [PAS], timing of swallow response) and electroencephalography (EEG) (latency and amplitude of pharyngeal event-related potential [ERP]).

Results

Acute stimulati

SUBMITTER: Tomsen N 

PROVIDER: S-EPMC6492367 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature