Cortical Pain Processing in the Rat Anterior Cingulate Cortex and Primary Somatosensory Cortex.

ABSTRACT: Pain is a complex multidimensional experience encompassing sensory-discriminative, affective-motivational and cognitive-emotional components mediated by different neural mechanisms. Investigations of neurophysiological signals from simultaneous recordings of two or more cortical circuits may reveal important circuit mechanisms on cortical pain processing. The anterior cingulate cortex (ACC) and primary somatosensory cortex (S1) represent two most important cortical circuits related to sensory and affective processing of pain. Here, we recorded in vivo extracellular activity of the ACC and S1 simultaneously from male adult Sprague-Dale rats (n = 5), while repetitive noxious laser stimulations were delivered to animalÕs hindpaw during pain experiments. We identified spontaneous

SUBMITTER: Xiao Z 

PROVIDER: S-EPMC6492531 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature