Hippocampal synaptic and neural network deficits in young mice carrying the human APOE4 gene.

ABSTRACT:

Introduction

Apolipoprotein E4 (APOE4) is a major genetic risk factor for late-onset sporadic Alzheimer disease. Emerging evidence demonstrates a hippocampus-associated learning and memory deficit in aged APOE4 human carriers and also in aged mice carrying human APOE4 gene. This suggests that either exogenous APOE4 or endogenous APOE4 alters the cognitive profile and hippocampal structure and function. However, little is known regarding how Apoe4 modulates hippocampal dendritic morphology, synaptic function, and neural network activity in young mice.

Aim

In this study, we compared hippocampal dendritic and spine morphology and synaptic function of young (4 months) mice with transgenic expression of the human APOE4 and APOE3 genes.

Methods

Hippocampal dendritic and spi

SUBMITTER: Sun GZ 

PROVIDER: S-EPMC6492660 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature