Overexpression of Paxillin Correlates with Tumor Progression and Predicts Poor Survival in Glioblastoma.

ABSTRACT:

Aims

To explore the prognostic and clinicopathological features of glioma with Paxillin (PXN) expression based on a large number of samples.

Methods

RNA sequencing data of 325 glioma samples from Chinese Glioma Genome Atlas (CGGA) database were obtained as discovery set. Three additional datasets were further obtained as validation sets. The protein expression pattern of PXN in glioma was measured by IHC. Kaplan-Meier survival and multivariate Cox analysis were used to estimate the survival distributions. Moreover, the functional annotation of PXN was also analyzed.

Results

In the discovery set, PXN overexpression was significantly associated with high-grade glioma as well as the higher mortality in survival analysis (log-rank test, P < 0.01). The results of the other

SUBMITTER: Sun LH 

PROVIDER: S-EPMC6492676 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature