Shared effects of the clusterin gene on the default mode network among individuals at risk for Alzheimer's disease.

ABSTRACT:

Aims

To explore the common effects of the clusterin (CLU) rs11136000 variant on the default mode network (DMN) in amnestic mild cognitive impairment (aMCI) subjects and remitted geriatric depression (RGD) subjects.

Methods

Fifty-one aMCI subjects, 38 RGD subjects, and 64 cognitively normal elderly subjects underwent resting-state fMRI scans and neuropsychological tests at both baseline and a 35-month follow-up. Posterior cingulate cortex seed-based functional connectivity (FC) analysis was used to obtain the DMN patterns.

Results

A CLU gene×disease×time interaction for aMCI subjects was mainly detected in the core cortical midline structures of the DMN, and the interaction for RGD subjects was mainly detected in the limbic system. However, they overlapped in two front

SUBMITTER: Ye Q 

PROVIDER: S-EPMC6492680 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature