Levodopa Effect on Basal Ganglia Motor Circuit in Parkinson's Disease.

ABSTRACT:

Aims

To investigate the effects of levodopa on the basal ganglia motor circuit (BGMC) in Parkinson's disease (PD).

Methods

Thirty PD patients with asymmetrical bradykinesia and 30 control subjects were scanned using resting-state functional MRI. Functional connectivity of the BGMC was measured and compared before and after levodopa administration in patients with PD. The correlation between improvements in bradykinesia and changes in BGMC connectivity was examined.

Results

In the PD-off state (before medication), the posterior putamen and internal globus pallidus (GPi) had decreased connectivity while the subthalamic nucleus (STN) had enhanced connectivity within the BGMC relative to control subjects. Levodopa administration increased the connectivity of posterior put

SUBMITTER: Gao LL 

PROVIDER: S-EPMC6492721 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature