Fibroblast growth factor 22 is a novel modulator of depression through interleukin-1β.

ABSTRACT:

Background and aims

Emerging evidence shows that fibroblast growth factor 22 (FGF22) plays a critical role in the etiology of depression. However, the molecular mechanisms of FGF22 are not fully comprehended. Here, the effect of FGF22 in depression and its relationship with interleukin-1β (IL-1β) were investigated in clinical, animal, and cell experiments.

Methods

Serum from depressive patients was collected, and the levels of FGF22 and IL-1β were analyzed by ELISA. The chronic unpredictable mild stress (CUMS) model was established, and primary hippocampal neuronal cells were cultured to examine changes in FGF22 and IL-1β levels in rat hippocampus.

Results

The results revealed a negative correlation between serum FGF22 levels and serum IL-1β levels. The expression of

SUBMITTER: Xu YH 

PROVIDER: S-EPMC6492756 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature