Asenapine modulates mood-related behaviors and 5-HT_1A/7 receptors-mediated neurotransmission.

ABSTRACT:

Aim

Asenapine is a new atypical antipsychotic prescribed for the treatment of psychosis/bipolar disorders that presents higher affinity for serotonergic than dopaminergic receptors. The objective of this study was to investigate its antidepressant-like and antimanic-like properties on relevant animal models of depression and mania and to assess the acute and chronic effect of Asenapine on dorsal raphe nucleus (DRN) 5-HT cell firing activity.

Methods

We assessed the effects of Asenapine using in vivo electrophysiological and behavioral assays in rats.

Results

Behavioral experiments showed that Asenapine had no significant effect on immobility time in the forced swim test (FST) in control rats. In the ACTH-treated rats, a model of antidepressant-resistance, Asenapine fa

SUBMITTER: Delcourte S 

PROVIDER: S-EPMC6492759 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature