Functional Genomic Analyses Identify Pathways Dysregulated in Animal Model of Autism.

ABSTRACT:

Background

Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental disorders that display complicated behavioral symptoms.

Methods

Using gene expressing profiling and the weighted gene co-expression network analysis (WGCNA), we studied genes coregulated by similar factors such as genetic variants or environmental effects in the hippocampus in an animal model of autism.

Results

From microarray data, we identified 21,388 robustly expressed genes of which 721 genes were found to be differently expressed in the valproic acid-treated group compared to the control group. WGCNA identified multiple co-expression modules known to associate with cognitive function, inflammation, synaptic, and positive regulation of protein kinase activating. Many of the

SUBMITTER: Huang JY 

PROVIDER: S-EPMC6492815 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature