Locus Coeruleus Dysfunction in Transgenic Rats with Low Brain Angiotensinogen.

ABSTRACT:

Aims

Transgenic TGR(ASrAOGEN)680 (TGR) rats with specific downregulation of glial angiotensinogen (AOGEN) synthesis develop cardiovascular deficits, anxiety, altered response to stress, and depression. Here, we evaluated whether these deficits are associated with alteration of the integrity of the noradrenergic system originating from locus coeruleus (LC) neurons.

Methods

Adult TGR rats were compared to control Sprague Dawley rats in terms of the following: tissue levels of transcripts encoding noradrenergic markers, tissue tyrosine hydroxylase (TH) protein level, in vivo TH activity, density of TH-containing fibers, behavioral response to novelty, locomotor activity, and polysomnography.

Results

TH expression was increased in the LC of TGR rats compared to controls.

SUBMITTER: Ogier M 

PROVIDER: S-EPMC6492901 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature