Cardiac Structure Doses in Women Irradiated for Breast Cancer in the Past and Their Use in Epidemiological Studies.

ABSTRACT:

Purpose

Incidental cardiac exposure during radiation therapy may cause heart disease. Dose-response relationships for cardiac structures (segments) may show which ones are most sensitive to radiation. Radiation-related cardiac injury can take years to develop; thus, studies need to involve women treated using 2-dimensional planning, with segment doses estimated using a typical computed tomography (CT) scan. We assessed whether such segment doses are accurate enough to use in dose-response relationships using the radiation therapy charts of women with known segment injury. We estimated interregimen and interpatient segment dose variability and segment dose correlations.

Methods and materials

The radiation therapy charts of 470 women with cardiac segment injury after breast ca

SUBMITTER: Duane FK 

PROVIDER: S-EPMC6493043 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature