Th2-T_RMs Maintain Life-Long Allergic Memory in Experimental Asthma in Mice.

ABSTRACT: Allergic asthma is a chronic inflammatory remitting-relapsing disease affecting the airways. Long-lived allergen-specific memory CD4⁺ T helper 2 (Th2) cells in mice persist in lungs for more than 2 years after the induction of experimental allergic asthma (EAA). To further understand lung Th2 memory cells, we tracked CD4⁺ T cells in spleen and lungs from healthy mice, through the initiation of acute EAA, recovery (remission), and allergen-induced disease relapse. We identified a lung CD3⁺CD4⁺ cell subset that expresses CD44^hiCD62L^-CD69⁺ST2⁺, produces Th2 cytokines, and mediates allergen-induced disease relapse despite treatment with FTY720 and anti-CD4 antibody. These cells reside in the lung tissue for

SUBMITTER: Bosnjak B 

PROVIDER: S-EPMC6493194 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature