Tenuigenin protects dopaminergic neurons from inflammation-mediated damage induced by the lipopolysaccharide.

ABSTRACT:

Background

Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNpc).

Aims

To study if tenuigenin (TEN), the main active component of Polygala tenuifolia, can protect dopaminergic neurons from inflammation-mediated damage in vivo.

Methods

We observed the effects of TEN on lipopolysaccharide (LPS) induced PD model by behavioral analysis, high-performance liquid chromatography, immunohistochemistry and enzyme-linked immunoadsorbent assay, etc.

Results

We showed that a single intranigral dose of LPSs (10 μg) induced microglial activation, reduced the survival ratio of tyrosine hydroxylase-immunoreactive (TH-ir) neurons in the SNpc and reduced dopamine (DA) conten

SUBMITTER: Yuan HL 

PROVIDER: S-EPMC6493587 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature